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Independent UK medicine guidance

Wegovy side effects: interactive UK body map

Most people who use Wegovy get at least one side effect early on, and for most it is a stomach or bowel symptom that eases as the dose settles. This page maps every effect listed in the current UK Wegovy leaflet to the part of the body it affects, explains what is normal, what may help, and which symptoms need a call to NHS 111 or 999.

Semaglutide, weekly injectionLeaflet revised June 2026Checked 20 October 2026Author: Nick Johnson, Medstack Ltd

Short answer. The UK leaflet lists nausea, vomiting, diarrhoea, constipation, stomach pain, headache and tiredness as very common (more than 1 in 10 people). Dizziness, indigestion, reflux, bloating, wind, gallstones, hair loss, taste changes and injection site reactions are common (up to 1 in 10). The serious ones to know are acute pancreatitis (uncommon), kidney or bladder stones (uncommon), severe allergic reaction (rare) and a very rare eye condition called NAION that can cause painless loss of vision.

Stop injecting and get urgent help for severe stomach pain that does not go away, and call 999 for swelling of the face, lips, tongue or throat or trouble breathing. This page cannot diagnose you. It summarises the official leaflet and NHS guidance.

Call 999Breathing problems, wheezing, or swelling of the face, lips, tongue or throat with difficulty swallowing.
Stop Wegovy and get urgent helpSevere, persistent pain in the stomach area, with or without being sick. It may spread to the back.

Explore Wegovy side effects by body area

Choose a point on the figure, or a body area from the list. Each panel shows what the leaflet says can happen there, how often it was reported, what tends to ease the mild version, and the point at which it stops being a side effect to manage at home. Frequency bands are taken from the Wegovy FlexTouch patient leaflet revised in June 2026.

Select a body area to begin

Pick a body area to start

Tap a point on the figure or choose an area from the list. You will see what the leaflet says can happen there, how often it was reported, what helps the mild version and when to get help.

General information only, not medical advice. It cannot tell you what is causing a symptom. Talk to your prescriber, pharmacist or GP if something worries you, use NHS 111 for urgent concerns and call 999 in an emergency.

Quick safety check

Four yes or no questions that point you to the right UK next step. Nothing is stored and nothing personal is asked. It cannot work out what is causing a symptom.

What the frequency words mean

Very commonMore than 1 in 10 people
CommonUp to 1 in 10 people
UncommonUp to 1 in 100 people
Rare / very rareUp to 1 in 1,000 / up to 1 in 10,000

These bands describe how often an effect was reported across trial populations. They do not predict what will happen to you, and a "not known" entry means the effect was seen after the medicine reached the market but the numbers are not good enough to estimate a rate. Some entries only apply to people with diabetes, and the panels above say so where that is the case.

Every listed Wegovy side effect at a glance

FrequencySide effects (Wegovy FlexTouch leaflet, revised June 2026)
Very commonHeadache, nausea, vomiting, diarrhoea, constipation, stomach pain, feeling weak or tired
CommonDizziness, indigestion, burping, wind, bloating, gastritis, reflux or heartburn, gallstones, hair loss, injection site reactions, taste changes, changed skin sensation, low blood sugar in people with diabetes; serious: complications of diabetic eye disease
UncommonLow blood pressure, light-headedness on standing, fast heartbeat, raised pancreatic enzymes, delayed stomach emptying, low blood sugar in people without diabetes, raised bilirubin (jaundice), injection site pain; serious: acute pancreatitis, kidney or bladder stones
RareSevere allergic reactions (anaphylaxis, angioedema), hip fractures
Very rareNAION, an eye condition that can cause painless loss of vision
Not knownBowel obstruction

Dose matters for two of these. The leaflet notes hair loss and changed skin sensation may be more frequent on the 7.2 mg dose than on 2.4 mg. It also lists feeling dizzy as a mainly first three months effect, and says the very common digestive effects usually go away over time.

Low blood sugar is listed twice for a reason: it is common in people with diabetes, especially those also on insulin or a sulfonylurea whose doses may need reducing before starting, and uncommon in people without diabetes. Warning signs include cold sweat, cool pale skin, headache, fast heartbeat, feeling sick or very hungry, vision changes, sleepiness, anxiety, confusion, poor concentration and shaking.

Why side effects cluster around dose increases

Weeks 1 to 16: escalationWegovy steps up from 0.25 mg every four weeks to reach 2.4 mg at week 17. Each step is a new level for the gut to adjust to, so symptoms often reappear briefly after each increase.
The first fortnight on any stepNausea and bowel changes are usually loudest in the days after a step up, then fade. Staying an extra four weeks on a step is a normal prescriber decision, not a failure.
Maintenance at 2.4 mg or 7.2 mgMost digestive effects settle by this stage. The 7.2 mg dose is for adults with obesity only, after at least four weeks on 2.4 mg, and brings a higher reported rate of hair loss and skin sensation change.

There is no exact timetable for one person. Do not move up early, and do not skip a step to "get it over with". If a missed dose has put you off schedule, the leaflet's five day rule is explained in our missed dose guide, and the full schedule is on the dose steps page.

What helps with the mild ones

Nausea & vomiting

Eat smaller amounts more often, chew slowly and stop before you feel full. Lower fat, blander and colder foods are often easier than rich, fried or spicy meals. Stay upright after eating. Sip fluids through the day rather than drinking a lot in one go. Injecting in the evening suits some people because the peak of nausea passes overnight; ask your prescriber before changing your injection time.

Red flag: severe persistent stomach pain is a stop-and-seek-help symptom, and vomiting that stops you keeping fluids down needs NHS 111.

Diarrhoea

Replace what you lose with small, regular drinks. A pharmacist can tell you whether an oral rehydration solution is suitable and whether an anti-diarrhoeal is appropriate for you. Avoid very sugary drinks, which can make it worse.

Red flag: blood in the stool, dehydration that is not improving, or being unable to keep fluids down needs NHS 111.

Constipation

Fluids are the first fix, because appetite suppression cuts your fluid intake too. Add fibre gradually, keep moving, and do not ignore the urge to go. A pharmacist can recommend a laxative suited to you. Do not stack several types on your own.

Red flag: no bowel movement for days plus stomach pain, swelling and vomiting could be an obstruction and needs prompt assessment.

Reflux, bloating & burping

Smaller meals, slower eating, fewer fizzy drinks, and staying upright for a couple of hours after your last meal of the day all help because the stomach is emptying more slowly than it used to. A pharmacist can suggest a suitable antacid or reflux treatment.

Red flag: reflux with severe pain, vomiting or difficulty swallowing needs clinical advice.

Tiredness & dizziness

Check you are eating enough overall, not just less. Very low intake plus dehydration is the usual driver. Stand up slowly. Do not drive or operate machinery while dizzy. If you take blood pressure or diabetes medicines, ask your GP whether the doses still fit your new weight.

Hair loss

Hair loss during rapid weight loss is usually a temporary shedding phase that recovers within months. Adequate protein and a general diet rather than an extreme one help. It is listed as more frequent at 7.2 mg. Persistent or patchy loss is worth a GP review to rule out other causes such as low iron or thyroid problems.

Injection site reactions

Rotate between upper arm, stomach and upper leg, and within each area move the spot. Use a new needle every time; blunt or reused needles cause more bruising. Take the pen out of the fridge a few minutes before injecting. Escalate to a pharmacist if a reaction is hot, spreading, leaking or lasting more than a few days.

Evidence checks: things people ask about

Headaches

Unlike some other weight loss injections, headache is a listed very common side effect of Wegovy in its own right. It is also one of the warning signs of low blood sugar. In practice, eating and drinking less is the usual driver, so fluid intake is the first thing to check. Persistent, severe or unusual headaches deserve their own assessment regardless of the medicine.

Mood, depression & suicidal thoughts

The MHRA and the European Medicines Agency have both reviewed reports of suicidal thoughts on GLP-1 medicines and found the available evidence does not support a causal link. That is a population conclusion, not a promise about any one person. If you have suicidal thoughts, get urgent help whatever you think the cause is: call 999 in an emergency, or use your local NHS urgent mental health helpline.

Thyroid cancer

The US label carries a warning about thyroid C-cell tumours seen in rodent studies. The UK leaflet does not carry an equivalent warning, and human data have not shown the same signal. UK prescribers still ask about personal or family history of medullary thyroid cancer or MEN 2 as a precaution, so mention it at your consultation.

Surgery and anaesthesia

The leaflet asks you to tell your doctor you are on Wegovy if you are due to have surgery under anaesthetic. Slower stomach emptying raises the risk of stomach contents entering the lungs during anaesthesia, and UK anaesthetists may ask you to pause the medicine beforehand.

Alcohol

Alcohol is not banned with Wegovy but it stacks with several listed effects: nausea, reflux, dehydration, dizziness and, in people on diabetes medicines, low blood sugar. Many people also find their tolerance drops as they eat less. Our Wegovy and alcohol guide covers this properly.

Where to get help in the UK

Call 999

Breathing difficulty, throat or face swelling, collapse, unresponsiveness, or hip pain after a fall with inability to stand.

NHS anaphylaxis guidance
NHS 111

Severe or persistent stomach pain, sudden vision changes, jaundice, unable to keep fluids down, much less urine than usual, or a suspected serious side effect.

111 online • Call 111
Your prescriber or pharmacist

Side effects that persist, recur or make you unsure about the next dose. The pharmacy that dispensed your pen has a duty to offer aftercare; use it.

How iGovy checks pharmacies
MHRA Yellow Card

Report any suspected side effect, including ones not in the leaflet. Wegovy carries the black triangle, meaning the MHRA specifically wants patient reports. It does not replace getting care.

Report via Yellow Card

In-depth guides to each side effect

Each guide goes deeper than the panel above: mechanism, trial figures, a step-by-step plan and the specific point at which to get help.

Nausea and vomiting

Why it peaks after dose steps, food and timing fixes, and when sickness means stop.

Constipation

A six step relief plan and the bowel obstruction signs the leaflet lists.

Dehydration and diarrhoea

Why thirst is blunted, the kidney warning, and a daily hydration routine.

Pancreatitis

Telling it from ordinary stomach ache, and the January 2026 MHRA update.

Gallstones

Why rapid weight loss raises the risk and the pain pattern to recognise.

Hair loss

The shedding and regrowth timeline, and the 7.2 mg note in the new leaflet.

Headache

Dehydration, blood sugar and caffeine causes, and the headaches that need 999.

Alcohol

How drinking stacks with nausea, reflux, dehydration and low blood sugar.

Frequently asked questions

What are the most common Wegovy side effects?

The UK leaflet lists seven very common effects, meaning more than 1 in 10 people: nausea, vomiting, diarrhoea, constipation, stomach pain, headache and feeling weak or tired. They are most noticeable when starting and after each dose increase, and the leaflet says they usually go away over time.

How long do Wegovy side effects last?

For most people the digestive effects peak in the days after a dose step and ease over the following weeks. Dizziness is described in the leaflet as mainly a first three months effect. Hair loss linked to rapid weight loss usually recovers over months. A symptom that is getting worse, not settling, or worrying you should be discussed with your pharmacist or prescriber rather than waited out.

Are side effects worse on 7.2 mg than 2.4 mg?

The leaflet specifically flags two effects as possibly more frequent on 7.2 mg: hair loss and changed skin sensation. Digestive effects at 7.2 mg were broadly similar to 2.4 mg in the trial that supported the higher dose, but individual tolerance varies. The 7.2 mg dose is only for adults with obesity and only after at least four weeks on 2.4 mg.

Should I take my next Wegovy dose if I still feel sick?

Mild nausea that is settling is usually not a reason to skip a dose, but severe symptoms are a reason to contact your prescriber first. Severe persistent stomach pain is different: stop the medicine and get urgent help. Never split, stretch or double doses on your own, and if you have missed a dose, follow the five day rule in the leaflet.

What does Wegovy pancreatitis pain feel like?

The leaflet describes severe, persistent pain in the stomach area, with or without nausea and vomiting, which may spread through to the back. It does not ease with a change of position or over the counter painkillers. This cannot be diagnosed online: stop using Wegovy and get urgent medical help. If pancreatitis is confirmed the medicine should not be restarted.

Can Wegovy affect my eyesight?

Two ways. In people with diabetes, a rapid improvement in blood sugar can temporarily worsen diabetic eye disease. In anyone, there is a very rare condition called NAION, at up to 1 in 10,000 people, that can cause painless vision loss in one eye. Sudden or rapidly worsening eyesight is an urgent same-day call to your doctor or NHS 111.

Why does Wegovy cause gallstones?

Losing a lot of weight quickly by any means raises gallstone risk, because the liver releases more cholesterol into bile as fat is broken down. Gallstones are listed as common on Wegovy. Severe pain under the right ribs, especially after eating, sometimes with fever, needs urgent assessment through NHS 111.

Can I drink alcohol on Wegovy?

There is no absolute ban, but alcohol makes several listed effects more likely: nausea, reflux, dehydration and dizziness. If you use insulin or a sulfonylurea it also raises the risk of low blood sugar. Many people find their tolerance drops because they are eating less, so smaller amounts go further.

Do I need to stop Wegovy before an operation?

Tell your surgical team you are on Wegovy. Because it slows stomach emptying, there is a higher risk of stomach contents being inhaled under anaesthetic, and the anaesthetist may ask you to pause the medicine for a period beforehand. Follow their instructions rather than the leaflet's general schedule.

How do I report a Wegovy side effect in the UK?

Through the MHRA Yellow Card scheme, online or via the Yellow Card app. Patients and carers can report directly and do not need a doctor to do it for them. Wegovy is under additional monitoring (the black triangle on the leaflet), so patient reports are actively wanted. A report is not medical advice; get care separately if you need it.

About this guide

Written by: Nick Johnson, founder of Medstack Ltd and Independent Prescription Pricing Analyst. Checked: 20 October 2026 against the Wegovy FlexTouch patient leaflet revised in June 2026. Next scheduled review: 5 December 2026, or sooner if the UK product information or MHRA safety advice changes. No clinician has reviewed this page; a named clinical reviewer will be added when one is appointed.

How this page was checked: every frequency band on the map and in the table was compared line by line with section 4 of the Wegovy FlexTouch patient leaflet revised June 2026 and section 4.8 of the Summary of Product Characteristics on the eMC, including the entries added in that revision (NAION, hip fractures, kidney and bladder stones, bowel obstruction, and the 7.2 mg notes). Trial figures come from the SmPC and the published STEP papers, never from pharmacy marketing. NHS pages supply symptom guidance and the MHRA Drug Safety Update supplies the pancreatitis wording. The page is re-checked whenever the eMC record changes or the MHRA issues a Drug Safety Update, and at least every three months.

Funding and independence: iGovy earns referral commission when readers use pharmacy discount codes on its price pages. No pharmacy or manufacturer paid for, saw or influenced this page, and health content is never adjusted for commercial reasons.

Change log: 5 September 2026: page rebuilt as an interactive body map with a four step safety check. Every effect in the June 2026 leaflet is now placed on the map, including the newer entries for NAION, hip fractures, kidney and bladder stones, bowel obstruction and the 7.2 mg notes on hair loss and skin sensation. Seven in-depth symptom guides (nausea, constipation, dehydration, pancreatitis, gallstones, hair loss, headache) published as a cluster and linked from each panel; injection sites shown as three syringe markers with arrows to the upper arm, stomach and thigh. 17 August 2026: original leaflet summary published.

Our role: iGovy is an independent price comparison site run by Medstack Ltd. It does not sell, prescribe or dispense medicines, and nothing here replaces the printed leaflet or advice from your prescriber, pharmacist or NHS services. Commercial arrangements with listed pharmacies do not influence this content. Wegovy is the brand name; semaglutide is the active ingredient. Spotted an error? Tell us through the contact page and see our editorial policy.

Primary sources:

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Original iGovy content, page structure, interactive body map and safety routing may not be copied, republished or used to create derivative works without permission.

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